Serotonin syndrome is something that becomes newsworthy amongst headache A recent study evaluated over 1700 patients who received sumatriptan.
Keep a list of all your medications so that all your doctors and other providers know everything you are taking. Mood disorders are common in migraine sufferers, and many people do take an SSRI or SNRI antidepressant, either for depression or for pain management. If you have concerns, contact the prescribing physician. It is important to stay on your prescribed medication—especially for antidepressants. When you are at the most risk for a problem with serotonin syndrome is when you have had a dosage increase, or when another medication that affects the serotonin system has been added.
Serotonin syndrome is a potentially life threatening drug reaction that causes the Brand names of triptans include sumatriptan (Imitrex), zolmitriptan (Zomig).
Brent J, Palmer R. Haddad and Winchester's Clinical Management of Poisoning and Drug Overdose. In: Shannon MW, Borron SW, Burns MJ, eds. 4th ed. Philadelphia, PA: Elsevier Saunders; 2007:chap 29. Monoamine oxidase inhibitors and serotonin syndrome.
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Risk of serotonin syndrome with migraine medication and anti-depressants. Triptans all work in the same way and are referred to as serotonin receptor agonists, meaning that they latch onto and stimulate serotonin receptors in the brain, which helps relieve the symptoms of a migraine headache.
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Serotonin syndrome can occur when triptans are taken by themselves, but the risk of its occurrence increases if you are also taking one of the SSRI or SNRI medications, because these anti-depressant and anti-anxiety drugs also work by increasing the amount of serotonin available at nerve endings. These medications are:.
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There are eight triptan medications currently approved for the treatment of migraine :
He’s held positions in drug advertising review, drug safety surveillance, medical information and marketing with several bio/pharmaceutical companies.
WebMD explains serotonin syndrome, a potentially fatal condition, including causes Amerge (naratriptan), Imitrex (sumatriptan), Maxalt (rizatriptan) and Zomig.
The condition is more likely to occur when you first start a medicine or increase the dose. Serotonin syndrome can occur if you are taking medications, particularly antidepressants, that affect the body's level of serotonin. The greatest risk of serotonin syndrome occurs if you are taking two or more drugs and/or supplements together that influence serotonin.
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Other prescription and over-the-counter drugs that can raise serotonin levels alone or in combination to cause serotonin syndrome include:
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Sumatriptan contraindications and the serotonin syndrome. Gardner DM(1), Lynd LD. Author information: (1)Faculty of Pharmaceutical Sciences, University of.
In addition, related reports from the proprietary manufacturers, the Health Protection Branch of Health Canada, and the World Health Organization Collaborative Centre for International Drug Monitoring were also solicited. A comprehensive search for reports of serotonin syndrome associated with sumatriptan use was conducted by using tertiary drug interaction literature, MEDLINE, EmBASE, Biological Abstracts, Current Contents, Reactions, ClinAlert, and the International Pharmaceutical Abstracts.
National Center for Biotechnology Information, U.S.